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Research focuses on the molecular genetic changes in oesophageal cancer using a whole genome sequencing approach to identify mutation signatures, epigenetic changes, gene mutation, deletions and insertions with specific relevance to early diagnosis and targeted therapeutic interventions in cancer. Is one of the very rare cardiologists in South Africa who is clinically active and trained in fundamental molecular laboratory methods, combining laboratory and epidemiological skills.

Widely published in both local and international journals and books of various topics related to cardiovascular medicine. Internationally recognized for her outstanding work in the area of heart failure. Collaborations with a range of prestigious national and international clinical and academic centers.

She holds an appointment as adjunct professor at the University of Queensland, Brisbane, Australia and as a visiting professor at the Baker Institute in Melbourne, Australia.

The Brain and Behaviour Initiative BBI enables cross-faculty, multidisciplinary, collaborative research in the cognitive and affective neurosciences and brings together expertise on phenotyping, genotyping, cognotyping, brain imaging and molecular signatures to address brain-behaviour issues.

New experimental techniques including brain imaging, genetic testing and neuropsychological assessment combined with new theoretical insights have opened up significant potential for the advancement of novel diagnostic tools and treatments for people with mental disorders.

The initial focus on trauma and resilience has now extended to work in substance use and NeuroHIV. Her research focuses on child lung health including HIV-associated lung disease, childhood pneumonia and childhood TB.

In she received the World Lung Health Award, awarded by the American Thoracic Society at a ceremony in San Diego, in recognition of work that has "the potential to eliminate gender, racial, ethnic, or economic health disparities worldwide".

Currently regarded as a thought leader in Rheumatic Heart Disease, both on the continent and internationally. Has significant international research collaborations within the Rheumatic Heart Disease Community and within the Cardiovascular Community. Her social responsibility is reflected in, amongst others, numerous board positions; and she continues to be involved in teaching, training and mentorship encompassing courses directed at nurse practitioners, clinical officers and echocardiography masterclasses in South Africa, Ethiopia, Zambia and Uganda.

Skip to main content. To end the call, select. Tip: When you have only one active voice call, to put the call on hold, press the call k[ Answer or reject a call To answer a call, press the call key. To mute the ringing tone of an incoming call, select.

To answer the call when the to uch screen is locked, swipe Swip e to answer from left to right. You can send a te xt message w ithout reje cting the call, informing the caller that you cannot answer the call.

To send the reply messag[ Go to the participant, and select. The conference call is put on hold on your device. The other participants can still continue the c onference call. To return to the conference call, select. To drop a participant, select , go to the participant, and select. To end the active conferen ce call, press the end key. Speed dial a phone number To a[ Voice dialling Your device automatically creat es a voice tag for the conta cts. Make a call with a voice tag Note: Using voice tags may be difficult in a noisy environment or during [ To view missed, received, and dialled calls, select Missed calls , Re ceived calls or Dialled numbers.

Tip: To open the dialled numbers list in the home screen, press the call key. To open the general log where you can monitor all voice calls, text messages, or data connections registered by the device, select the general log tab.

Subevents, su ch as a text m essage sent in more than one part and packet data connections, are logged as one communicat ion event. Virtual keyboard You can use the virt ual keyboard in lands cape mode. When using the virtual keyboa rd in full screen mod e, you can select keys with your fingers.

When you tap an item, the current input method view closes, and the selected one opens. Handwriting The input methods and languages sup porte d by the ha ndwritin g recognition vary by region and may not be available for all languages. Write legibl[ To add an emoticon, select Inse rt emoticon. Traditional text input Tap a numbe r key repeatedly until th e desired character appears. There are more characters ava ilable for a number key than a[ Train the device to recognise your handwriting bette r.

This option is not available in all languages. Manage names and numbers To copy or delete a contact , or to send a con [ Default numbers and addresses You can assign defa ult numbers or address e s to a contact. If a contact has several numbers or addresses, you can easily call or send a message to a certain number or address.

The default number is also used in voice dialling. In the contacts list, select a contact. Select a [ Copy contacts When you open the contacts list for the fi rst t ime, the device as ks if you want to copy names and numbers from th e SIM card to your device.

To start copying, select OK. If you do not want to copy the contacts from the SIM card to your device, select Cancel. The device asks if you want to view the SIM card contacts in the contact[ When security features that res trict calls are in use such as call barring, closed user group, and fixed dialling , calls may be possible to the official emergency number programmed into your device. Call barring and call diverting canno t be activ e at the same time. You need your PIN2 code to activate and deactivate fixed dia lling or edit your[ You can c[ Send a text or mult imedia message — Select New message.

Select recipients or groups f rom the contacts list — Select from the toolbar. Enter the numbe r or mail address manually — Tap the To field. Enter the sub ject of the ma il or multimedia [ Multimedia messages Important: Exercis e caution when opening messages.

Mess ages may contain malicious software or otherwise be harmful to your device or PC. You may receive a noti fication that a multimedia message is waiting in the multimedia message cent re. To start a pa cket data con nection to retrieve the message to you r device, select Opt[ To set up e-mail from your home screen, select the relevant plug-in. E-mail service The e-mail service on your Nokia device automatically transfers e-mail from your existing e-mail address to your device. You can read, respond to, and organise yo ur e-mai[ When you open the mailbox, the device asks if you wa nt to connect to the mailbo x.

To connect to your mailbox a nd retrieve new e-mail headers or messages, select Yes. When you view messages online, yo u are continuously connected to a remote mailbox using a data connection.

To view previ[ To view e-mail attach ments, open the messag e, and select the attachment field indicated by. Setting the device to ret rieve e-mail au tomatically may [ Mail for Exchange With Mail for Exchange, you can receive yo ur work e-mail to your device.

You can read and reply to your e-mails, view and edit compatibl e attachments, view calendar information, receive and reply to meeting requests, schedule meetings, and view, add, and edit contact information. ActiveSync Use of the Mail for Exchange applicati[ Before you can view SIM messa ges, you must copy them to a folder in your device.

A list of folders opens. To start copying, select a folder. To view the[ To receive messages automatically in your home network, select Auto in home netw. Outside your home network, you receive a notification that there is a message to retrieve in the multimed ia message centre.

If y ou select Always automatic , your device automatica[ The name you give to the new mailbox replaces Mailbox in the Messaging main view. You can have up to six mailboxes. Select Mailboxes and a mailbox to change the co nnection settings, user settings, retrieval settings, and automatic retrieval settings. Chat About Chat Select[ Personalise your device You can personalise yo ur device by chang i ng the home screen, tones, or themes.

You can use themes to change the look of the display, such as wallpaper and ma in menu layout. To change the theme that is used for all the applications in [ When the ti me expires, the profile changes back to the previously acti ve non-timed profile. When the profile is timed, is displayed in the home screen. The Offline profile cannot be timed. To create [ To fast-forward or rewind, select and hold or.

To go to the next item, select. To return to the beginning of the item, select. To skip to the previous item, select again within 2 seconds after a song or podcast h as started.

To repeat the current item , all items [ If you select Yes , select artists to find t he songs you wan t to add to the play list. Select Add to add items. To show the song list under an artist title , select Expand. To hide the song list, select Collapse. When you have made your selections, select Done. If a compatible memory card is insert ed, the playlist is sa ved to the memor[ If you ar e using a USB data cable, select Mass storage as the connection mode.

A compatible me mory card must be inserted in the device. Downloading music may in volv e additional costs and th e transmission of large amounts of data network service. Fo r information about data transmission charges, contact your network service provider. To access Ovi Music, you must have a vali d internet access point in the device. You may be asked to select the acces s point to use when connecti[ To start a downloa d, select the episode title.

Y ou can download multiple episodes at the sa me time. Fully downloaded p[ Depending on the s etup of your device, there are the following options: device memory[ Select th e cur rent lighting conditions.

This allows the camera to reproduce colours more accurately. For [ To capture an image, pre ss the capture key. Do not mov e the device before the image is saved and the final im age displayed. To zoom in or out when capturin g an image, use the zoom slider. To leave the camera open in the background and use other a pplications, press the menu key. T o return to the camera , press and hold the capture key. Tip: Select 2 seconds to keep your hand steady when capturing an image.

To close the settings window, tap the screen [ To stop recording, press the capture ke y. The video clip is automatica lly saved in Gallery. The maximum length of a vide o clip is approximately 30 seconds with sharing quality an d 90 minutes with other quality sett ings. Video recording cont rols and indicators The video viewfinder displays the following: 1 — Mode ind icator 2 — Audio mu[ To return to the viewfinder to record a new video clip, press the capture key.

Tip: To access the im ages and video clips view quickly, tap[ The images, video clips, and folders are or dered by date and time. To browse the files, swipe up or down. To open a file, select a file from the list. When viewing an imag e, to view the next or previous image, swipe the image left or right, respecti vely. To zoom in an image, use the volume key in your device. Select Options and from the followi[ Nokia Video Centre With Nokia Video Centre network servic e , you can download and stream video clips over the air from compatible inte rnet video services using a packet dat a connection.

You can also tra nsfer video clips from a compati ble PC to your device and view them in Video centre. The downloaded video clips are saved in My videos. When the video clip is playing, to use the cont rol keys for controlling the player, tap the screen. To adjust the volume, use the volume key. Warning: Continuous exp[ The content of the installed video services is distributed using RSS feeds.

To view and manage your fee ds, select Video feeds. Select Via Video dire[ To view your device on a PC as a mass memory device where you can transfer any data files, connect using a USB data c able. Select M ass storage as the co nnection mode. A compatible memory card needs to be inserted in the device. Select the video clips you wa nt to copy from y our PC. Transfer the video clips to E:My Vide os in the me[ Catch up on the news and visit your fav ourite websites.

You can use you r device web browser to view web pages on the internet. To browse the web, you must have an in ternet access point configured in your device and be connected to a network. Subscribe to a web feed You don't have to visit your favourite websites regularly to keep up with what's new on them.

You can subscribe to web feeds and ge t links to latest content automatic ally. Web feeds on web pages are u[ Check the type of access p oint you need with your serv ice provider for the service you want to access.

For a vailability and subscription t o packet data connection services, contact your service provider. If you skip this step, you are asked to select a connection method an d to define the settings needed.

To edit the settings of an access point, open one of the acce ss point groups, and select an access poin t. Follow the inst ructions from your service provider. To edit a packet data access point, open one of the access point groups, and select an access point marked with. Follow the instructions from your service provider. To view the details of a conne[ Bluetooth connectivity About Bluetooth connectivity With Bluetooth conn ectivity, you can ma ke a wi reless connection to other compatible devices, such as mobile devi ces, computers, headse ts, and car kits.

You can use the connection t o send images, video and sound clips, a nd notes, transfer files from your compatible PC, a nd print images with[ To hide your device from other devices, select Hidden. Select the device with which y ou want to co nnect. If the other device requires pairing before data can be transmitt ed, a tone sounds, and you a re asked to enter a passcode. The same pa sscode must be entered in both devices. When the connection is established, Sending data is di splayed.

Tip: When sea rching for devices, some devices may[ To cancel all pairings, select Option[ Before the remote SIM mode can be activa ted, the two devices must be paired and the pairing initiated from the other device.

When pairing, use a digit passcode, and set the other device as authoris ed. To use the remote SIM mode with a compatible car kit accessory, activate Bluetooth connectivity, and enable the use of the remote SIM mode with[ Sta rting an active p acket data connec tion for examp le, to send and receive e-mail is quicker than if the de vice establishes a packet da ta connection when needed.

If there is no pa[ About Ovi Store In Ovi Store, you can download mobile games, application s, videos, images, themes, and ringing tones to your device. Some items are free of charge; others you need to pay for with your credit card or in y[ To turn off the alarm when t he alarm expires, select Stop. To snooze the alarm, select Snooze. If your device is switched off when an alarm expires, your device switches itself on and start s sounding the alarm tone.

To define the snooze time, select[ File manager About File manager Se[ These options are available on ly if a compatible memory card is inserted in the device.

To install an applicat ion, do the following: 1. In othe[ If you remove software, you can only reinst all it if you have the original software package or a full backup of the removed so ftware package.

If you remove a software package, you may no longer be able to open documents created with that software. If another software package depends on the software package that you removed, the other software pac[ To play a video clip , select Video clips , and a clip.

To list recently played files, in the application main view, select Recently played. In the list of video clips,[ The content is not sav ed in your device. With the Recorder application, you can record voice memos and telephone conversations.

The recorder cannot be us ed when a data call or GP RS connection is active. To record a sound clip, select. To stop r[ Converter With Converter, you can convert mea sures from one unit to another. The converter has limited accuracy , and rounding errors may occ ur.

To translate words from one languag e to another, enter tex t in the sear[ Voice commands To activate enhance d voice commands, to start ap plications and profiles, press and hold the call key in the home screen. To control your device with en hanced v oice commands, press and hold the call key in the home screen, and say a voice co mmand. The voice command is the name of the application or profile displayed in the list. In application se ttings, you can edit the se ttings of some of the applications in your device.

With Device updates, you can connect to a server and receive configuration [ PIN2 code, contact your service provider. If y ou forget the lock code, contact a Nokia Care point or your service provider. To avoid unauthorised use of your device, change the lock code.

The preset code is